Cerebellar-Cortical Control:
Cells, Circuits, Computation, and Clinic
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Neural Computation Group |
The Neural computation group is interested understanding the cellular basis of neural computation in the mammalian brain, specifically, how the integrative properties of neuronal dendrites and the anatomical and functional connectivity of neural circuits contribute to coding and processing of information in the intact brain. The lab combines in vitro and in vivo imaging and electrophysiology, and takes advantage of a range of high-tech approaches developed in the lab. These include two-photon imaging techniques, patch-clamp recordings from axons and dendrites and simultaneous recordings from multiple synaptically connected cells. Such electrophysiological and imaging approaches to study circuit function are now being complemented by high-throughput 3-D electron microscopy to establish the underlying connectivity of the circuit. The experiments are tightly linked to computational models of single neurons and networks of neurons.