Seminars are open to all visitors and start Monday at 16:00 sharp. Coffee and tea will be served from 15:45. The seminar series lectures are in a colloquiumzaal at the third floor (entrance level) of the Faculty building of Erasmus MC.
Carlos Dotti
Neuronal Polarity: intrinsic-extrinsic inter-dependence
| 2008-11-03 | Room: Be 425 |
One of the goals of our group is to unravel the basic mechanisms of neuronal polarization, i.e. the position of axon and dendrites in a neuron. This process starts with the migration of the last post-mitotic neuroblasts from the germinal layer to their final destination in the cortical layer; the generation of short cytoplasmic extensions serving as sensors for the extracellular environment and a stop-signal to determine its final positioning. The accuracy of this process is of fundamental importance for the proper neuronal connectivity. To address this issue, we have largely relied on neuron differentiation experiments with rodent embryonic hippocampal neurons in vitro. The current project will study this process in an in situ environment using wild type as well as genetically modified mice and Drosophila melanogaster.