Seminars are open to all visitors and start Monday at 16:00 sharp. Coffee and tea will be served from 15:45. The seminar series lectures are in a colloquiumzaal at the third floor (entrance level) of the Faculty building of Erasmus MC.
Frank Bradke
Max Planck Inst. Martinsried, DE
Intracelllular mechanisms of axonal growth and regeneration.
| 2009-05-04 | Room: Ae 406 |
Lesions in the Central Nervous System (CNS) in mammals have devastating effects because injured axons do not regrow. The CNS myelin and the scar tissue that surrounds the lesion as well as cell-intrinsic mechanisms restrain the growth of injured axons. While there has been a great deal learnt about the key extrinsic factors that contribute to the inhibition of axonal regrowth the intrinsic mechanisms that control axonal growth or pause behaviour are still elusive. The goal of my laboratory is to understand how axonal growth is regulated in injured and uninjured neurons. To acquire such knowledge we manipulate the growth state of neurons both in vitro and in vivo and we create new ways to overcome the inhibitory environment of the CNS, a pre-requisite for any therapy of spinal cord lesions. We use cell biological, videomicroscopy, molecular and biochemical approaches and also study spinal cord injury in vivo.