Seminars are open to all visitors and start Monday at 16:00 sharp. Coffee and tea will be served from 15:45. The seminar series lectures are in a colloquiumzaal at the third floor (entrance level) of the Faculty building of Erasmus MC.
Richard Vallee
Role of Molecular Motors in Neural Stem Cell Migration
| 2008-04-07 | Room: Coll. K |
During brain development, neural precursor cells migrate along radial glial fibers to populate the neocortex. Neuronal migration defects are responsible for many brain developmental disorders including lissencephaly (the smooth brain disease), double cortex and periventricular heterotopia. Migratory neurons extend a long leading process from the cell soma, and subsequently the soma moves in the direction of the leading process in a discontinuous or saltatory manner. RNA interference in live brain embryonic slices has revealed specific roles for dynein and myosin motor proteins during migration.